bcachefs is way more flexible than btrfs on multi-device filesystems. You can group storage devices together based on performance/capacity/whatever else, and then do funky things like assigning a group of SSDs as a write-through/write-back cache for a bigger array of HDDs. You can also configure a ton of properties for individual files or directories, including the cache+main storage group, amount of data replicas, compression type, and quite a bit more.

So you could have two files in the same folder, one of them stored compressed on an array of HDDs in RAID10 and the other one stored on a different array of HDDs uncompressed in RAID5 with a write-back SSD cache, and wouldn't have to fiddle around with multiple filesystems and bind mounts - everything can be configured by simply setting xattr values. You could even have a third file which is striped across both groups of HDDs without having to partition them up.