Me too. Stock from the install guide, Linux and linux-lts kermels

What doesn't work :

ftdi chipsets over usb aren't recognized by the software anymore.
The menu to switch on/off WiFi hangs, crashes the subsystem (and the menu panel), must reboot.
Laptop goes asleep when and if it feels like, sometimes doesn't even shut down the screen when I close the lid (dell 7389). And wakes up randomly of course.
Impossible to get snapper-rollback to work ; snapshots work, rebooting in an earlier config doesn't (and that part of the wiki is a mess).
Helvum doesn't show the audio hardware and software, no way to route stuff like we used in Jack.
Webcam, internal microphone don't work.
External output/input hardware (minijack) don't work.
Appimages don't work natively, must decompress and launch from terminal