Ghost in the Shell and Serial Experiments Lain are classics you can't go wrong with.

If you want something to laugh at check out Grand Blue

Something to laugh at but it is an isekai The Eminence in Shadow or KONOSUBA

Or an SOL to laugh at BOCCHI THE ROCK!

• ODDTAXI (absolutely amazing)
• Madoka Magica (watch until ep 3 at least)
• Land of the Lustrous (very different animation style)
• Vinland Saga (great story)
• Your Name. (great romance)
• Baccano! (very interesting style of storytelling. The characters feel like something you'd see in a theatre)
• Dorohedoro (weird, but interesting)
• Dororo (just two good friends adventuring)
• Made in Abyss (gets good, but really takes those 13 episodes for that)

• 86: A commander named Lena commands a drone squad against an autonomous robot army. The drone squad is populated by the Colorata minority, the 86.
• Gakkougurashi!: Just watch it. Don't look up ANYTHING about it.
• Violet Evergarden: A child soldier discovers what it's like to be human. Don't marathon this. It will make you cry
• Little Witch Academia: Anime Harry Potter
• Mob Psycho 100: Psychic kid is mentored by con artist claiming to be psychic.
• MagiRevo: Princess with no magical powers wants to fly so develops magicology. She takes in Euphyllia, her brother's ex-fiancee, as an assistant.

Demon slayer
Oshi no Ko
Hell's paradise

Have you watched much of anything before? Likes? Dislikes?

My absolute favorite has always been Samarai Champloo. Same creator, also fantastic Coyboy Bebop.

Others I enjoyed:
Mob Psycho 100 & One Punch Man (same creator behind both)
Berserk (I've only seen the 3 movies for Golden Age on Netflix)
Attack on Titan / Shingeki no Kyojin
Trigun (I loved the original, but the recent remake was decent)
Dorohedoro (Incomplete, not sure if getting 2nd season)
Deathnote
Fullmetal Alchemist

If you liked Cyberpunk 2077, you might also like Psycho-Pass. It depicts a sci-fi future where they attempt to prevent crime by measuring peoples mental state to varying degrees of success. It's widely considered a great show and a quintessential Sci-Fi Anime.

I recommend Jujutsu Kaisen.

A very niche one Niea under 7 (stylized "NieA_7) but is great

Has anyone recommended Gundam yet? No? Good, I'm recommending Gundam.
Now, the whole thing might confuse you, and there are a ton of separate Gundam shows each one in it's own continuity. So, to make things simple, I'm going to just suggest two of them. The currently airing Gundam: Witch From Mercury, and the classic that started everything, Mobile Suit Gundam.
The 3 compilation movies of the classic Gundam are on the Gundam.info Youtube channel for free right now, by the way! There's several other shows in that channel and you might even be able to watch G-Witch depending on your location.

Patlabor, specifically "Patlabor ON TELEVISION" and "Patlabor New Files" (sometimes called New OVA) are about a very comfy close-future environment about a group of police who are under the division for dealing with any mech incidents, meaning giant robot fights will happen in a very down-to-earth setting

I also recommend the movies if you enjoy the GITS movie as it's the same director and he likes exploring a various amount of social commentary, from criticism of institutional inefficiency to existential reflections, (just dont watch the 3rd movie, it has nothing to do with anyone who made the original Patlabor)

There's also the original Patlabor OVA, but I personally didn't enjoy that nearly as much as the tv anime, and some of the characters act a little different, so it might be jarring if you watch that before the tv anime despite it being chronologically made first

Fullmetal Alchemist: Brotherhood

Made in Abyss

Seishun Buta Yarou wa Bunny Girl Senpai no Yume wo Minai

Steins;Gate

In no particular order here are some that I like that I haven't seen recommened yet:
86
Vinland Saga
Mashle: Magic and Muscles
Steins Gate
Monster

Chainsaw Man

Spy x Family

Bocchi the Rock

One Piece

Death Note

Call of the Night

Jujutsu Kaisen 0

Hunter x Hunter (2011)

Cowboy Bebop

Bubble

Ya Boy Kongming

For Shonen I recommend Hunter x Hunter and Jo Jo Bizarre Adventure!

Could maybe try kekkai sensen, has a second season called beyond iirc

I just watched Akiba Maid wars. it was an absolutely nonsensical series, recommend it.

Paranoia Agent

Have you watched the popular stuff like Attack on Titan or Death Note?

my recommendation in general or for anyone looking for something different is Sonny Boy. the show is about a class of kids finding themselves alone after their school suddenly comes to exist in a black empty void, or, "going adrift" as they put it. alongside this they each also manifest odd powers from bending reality entirely to making their fingertip glow.

this premise expands a lot in the show in ways you really cannot predict. it's completely bizzare and very sentimental. it's a short show at 12 episodes, but absolutely one of my favorite shows of all time and very unique. i've recommended it several times to many people and everyone i know has loved it.

Nichijou (日常). On the surface it is an absurdist slice of life comedy with very good animation and an unique art style. If one looks harder, many skits look to be animated koans. The very first skit of the first episode is a good example. 10/10

Yu Yu Hakusho. The old school battle shounen that the author of hunterXhunter first major success. Starts with some interesting ghost stuff and then veers more into a more traditional battle shounen including one of the best tournament arcs ever.

Re: Zero

A guy gets sucked into an Isekai (what he thinks is a typical otherworld fantasy that he's read about) but despite being genre savy he painfully learns that it's not exactly like that. He doesn't get cheat codes to make him powerful and beloved like in those wish fulfilment books/anime he consumed. If he wants a better life then the one he gladly left behind he will have to put in effort and improve himself. Luckily (or unluckily) he will get multiple chances as he has received power of time looping after his (usually extremely painful) deaths.

• Loneliness/body horror, Adventure, fun time

A Place further then the Universe. An incredibly inspirational story of four teen girls who decide to go to Antarctica. Other then dealing with grief this doesn't have anything upsetting. Just the ultimate feel good motivation show.

Welcome to the N.H.K

It's all a conspiracy. Sato is a college dropout neet/hikomori (not in education employment or training due/acute social withdrawal. Also easily addicted and very conspiratorial in part due to an old HS crush). A mysterious high school girl appears one day and declares she wants to save him from his lifestyle for her own selfish and mysterious reasons. That is the start to a very dark journey as he attempts to recover but on the way stumbles into a lot of troubling japanese social trends.

Monster. The actions of a well meaning Japanese surgeon unleash a monster on the world, the doctor travels around post communist Germany and Czechoslovakia going deeper and deeper into the mystery of the Monster and looking for a way to stop him. But can he do what is necessary even if it breaks the Hippocratic oath?