I mean...yeah, but...

• Are you trying to just have static information? Like, prewritten webpages, no database with information that's used to generate webpages on-the-fly?

• Are you making a blog? That's something that a number of people do for personal websites, and there's specialized software to do that.

• Is this basically going to be maintained by one person? In that case, what they already know may be a factor.

• Roughly how many webpages do you expect to create for the website?

I mean, if I were going to make a website with a single static page, I'd just write the thing by hand in HTML in emacs. I know (old, and not at a professional level) HTML and I know emacs. That's a good choice for me, but would be wildly unreasonable for, say, my mother, who doesn't know either.

If I were trying to create a blog, I'd probably use existing blogging software of some sort (and I don't know if I'd self-host that blog).

If I were setting up a dynamic website --- database, software that generates webpages from that database --- that other people might maintain in the future, I'd probably look to use some kind of popular framework using a widely-used language. At that point, whoever is making the website is probably going to need to know some degree of programming.

There's software that's designed to make it easier to update the theme across an entire website spanning tens of thousands of pages. That's useful if you have a website having tens of thousands of pages, but might very well be a waste of time if you just want to put up a handful.

I'm just illustrating that what you'd use varies wildly based on the size of the website, what the people who will be maintaining it already know, and whether you want dynamically-generated content.