A Vampyre Story worked nice on Wine on an old computer with Mint Xfce when I played it last year. Only had to set Wine as windowed full screen, since the game got issues when alt-tabbing. Also worth noting it requires DirectX on Windows, so you'll have to use DXVK.

Haven't seen any PICO-8 games lag on Linux, and both Celeste Classic games were released on PICO-8.

Dust: An Elysian Tail might be playable, bar maybe two areas (one mandatory) that have a lot going on.

Slay the Spire should run fine, but I had to sideload an older version of OpenJDK to get it working (maybe 8 or 11; don't remember which exactly).

Songs for A Hero also seems to run fine.

Tanglewood is a Mega Drive homebrew, so should be playable on any emulators your PC can run.

Va-11 Hall-A: Cyberpunk Bartender Action also runs fine.

Böbl and Nix: The Paradox Relic should both run fine on NES emulators.