Absolutely! Currently running Diablo 4 on the SteamDeck using Proton Experimental. Runs perfectly on medium-high settings at 45-50 fps. It's insane how far we've come. When I first started using Linux over ten years ago, running Windows games was nigh-impossible. And Valve finally released their Steam client for Linux, the selection of games was ... very limited.

I wouldnt limit yourself to native linux. Check out protondb.com. You can even use non-steam games through steam for use with proton (or if you're feeling more technical you could use other tools that are more hands on).
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