fullsquare
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1514
fullsquare

@awful.systems

fullsquare 5 points 4 days ago

so what i'm getting from this is the only kind of progress openai and friends are capable of is progressing from slop grenades to slop airstrikes, and so far it only works because they have good marketing, augmented by their own bot farms, and because money is all you need, and so far they haven't ran out of money

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fullsquare 6 points 5 days ago

never have to shower again

Some marketing claims should remain untested

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fullsquare 1 point 4 days ago

Bet some bacteria would feed on it anyway if you give it enough time

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fullsquare 7 points 6 days ago

people forget that there are areas in russia, not very far away from there, where plague is endemic in wild rodents

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fullsquare 243 points 10 months ago

acab includes paw patrol

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fullsquare 147 points 5 months ago

i hope he's not remembered at all, like his cause (someday)

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fullsquare 137 points a year ago

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fullsquare 121 points 4 months ago

grey - šŸ‡¬šŸ‡§ english (traditional)

gray - šŸ‡ŗšŸ‡ø english (simplified)

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fullsquare 121 points 24 days ago

no no, it makes sense. alpha male, so not ready for release and bugs are to be expected

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fullsquare 120 points 7 months ago

average euro prices of fuels would kill american on contact

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fullsquare 117 points 12 days ago

I think that advertising is much more harmful than commonly thought of

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fullsquare 107 points a year ago

the problem is that there is natural (as in, unmodified) cheap generic insulin available, it's just that it sucks compared to everything else. you see, insulin is a peptide that is supposed to appear, do some signalling, then disappear and unmodified insulin copies this thing exactly. the problem is, most of the time when peptide is supposed to work as a pharmaceutical, you don't want to do that, you'd like insulin to last longer than usual, which means changes to it that make breakdown slower, or adding something that makes it stick to albumin, which has similar effect because it hides insulin somewhere enzymes can't reach it and also it makes it start acting slower. this means less frequent dosing and less changes in insulin activity over time. there are also other insulins that start acting faster than natural, and this is also due to a couple of modifications in its structure

for another example, ozempic was not the first drug in its class, it's also a modified peptide, and it can be injected s.c. once a week, compared to previous iteration (liraglutide) that requires daily injections. if natural peptide is injected i.m. instead, its halflife is half an hour, and in serum it's only two minutes (it gets released a bit slower than it is metabolized)

manufacturing costs are about the same for any variant, most of it is in purification. patents for a couple of these have expired anyway by now, but if manufacturing is limited then price can be set arbitrarily high (see daraprim)

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fullsquare 106 points 6 months ago

edited news segment with jd vance and caption single person clapping

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fullsquare 105 points 4 months ago

god forbid a man has hobbies

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fullsquare 102 points a year ago

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fullsquare 78 points 10 months ago

lies, 5.42kb

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fullsquare 75 points 3 months ago

the man who decided to end german nuclear power production getting a seat in gazprom doesn't inspire confidence in reality-based discussion of this subject

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fullsquare 75 points a year ago

-4 charisma -5 endurance (smog) +2 seafaring/navigation +15 capacity of central base storage (british museum)

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fullsquare 74 points 4 months ago path: 0 24403338, hotness: undefined, score: 74, children: 0
fullsquare 74 points a year ago

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thanks for using Leebra!

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