TIL Social Pain (rejection) and physical pain overlap parts of the same neural pain pathway, and acetaminophen (paracetamol) alleviate social pain. Proof of social pain hurts as much as physical pain

a year ago by CatDogL0ver to c/til

In a double-blind, randomized, placebo-controlled trial, we found that daily acetaminophen administration significantly reduced experiences of social pain over 21 days, but only for individuals exhibiting high levels of forgiveness. Keywords: Social ...

N.B. This is a serious topic. Please stop spreading propaganda about acetaminophen being addictive or causing autism. Please read the study. The point of the study is not about acetaminophen. It is about social pain can hurt as much as physiological pain. Only people with trait of high level of forgiveness responded to acetaminophen. Acetaminophen will not work for you if you not a kind. forgiving person. No need to worry about acetaminophen if you have a weak trait. Kindness can be learned by not trolling

Social pain (psychache), such as ostracisation/rejection/bullying, can hurt as much as physical pain. Forgiveness and acetaminophen have interactive effects on experiences of social pain. Telling victims to just "let it go" is just like withholding pain medicines from patients recovering from surgery.

We need to tell the victims that psychological wounds are like physical wounds. They will heal but the healing processes can be long and painful. Psychological pain may come back in waves, and the scars may remain just like physical scars. If the psychological pain is unbearable, don't hesitant to seek mental health. "It's okay not to be okay." Don't be persuaded to think "it is all in the head." Psychological wounds are as real as physical wounds. Good luck.

FoxyFerengi 58 points a year ago

This is pretty funny given the recent political assertions that Tylenol causes autism, because rejection sensitive dysphoria is a symptom of autism/adhd

Edit: that N.B. is pretentious as fuck. Don't take an incredibly tiny study with very little scientific traction as fact. Presenting it as fact demonstrates how little the OP understands about research

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peoplebeproblems 31 points a year ago

Wait

I'm abnormally sensitive about rejection because of my AuADHD?

What the flipping fuck. Fuck this shit. What drugs just turn off my brain so I can just be a blob of flesh until I die of old age since they don't like how often I complain about existence being so goddamn difficult.

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Rooty 13 points a year ago

Sheesh, tell me about it, just about every quirk of my personality turns out to be an ADHD symptom in the end.

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FoxyFerengi 11 points a year ago

I hear you, I'm ND too. Reading about things like RSD being common in people like us has at least helped me be easier on myself.

Existence is goddamn difficult and I wish I had an answer, because turning my brain off sounds wonderful. Alcohol can do that, but it comes with some awful consequences. I've also abused quetiapine, but eventually that fucked me up too. Weed does not play nice with my brain

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peoplebeproblems 8 points a year ago

Man quetiapine just made me panic and feel like I couldn't breathe. Actually there are a shit ton of "sedating" medications that do that to me thinking about it.

Except of course benzos, but thanks to those being cross tolerant with z drugs, they really gotta pump those in me to work at all.

I've had a little success with clonodine.

I remember abilify completely shut off my ability to think. Still had emotions, just no reasoning.

People talk about Dating being this thing that's easy to do. Yeah. Maybe if you had any choice over what was and wasn't difficult.

Im thinking about walking into therapy tomorrow and just asking "do I have to work if I'm just gonna be miserable anyway?"

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FoxyFerengi 8 points a year ago

I'm on clonidine for ADHD. I can actually stop myself from speaking out of turn now, so maybe it has been a little sedating xD

Dating is kind of a nightmare. I know people say anyone can find a partner, but that doesn't take into account things like sensory issues or hard boundaries around other things that keep us sane. I told myself a few years ago that I didn't want to date while I'm university, but honestly it's been so nice not forcing myself to fit into other people's boxes that I might just stay single even after I earn my doctorate

I'm also with you on refusing to participate in a misery machine for a living. I hope you can hash out some kind of misery escape plan with your therapist tomorrow

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Kolanaki 3 points a year ago

What the flipping fuck. Fuck this shit. What drugs just turn off my brain so I can just be a blob of flesh until I die of old age since they don't like how often I complain about existence being so goddamn difficult.

Marijuana.

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Angelevo 6 points a year ago

Different people react differently to molecules. In some people (I think higher prevalency in people with Autism/AD(H)D) the THC is more likely to cause psychosis.

These things are not "one size fits all", at all.

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FoxyFerengi 3 points a year ago

Edit: When I made this comment the person above was being unfairly down voted. What they said has scientific merit and the reader can easily verify.

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shnizmuffin 2 points a year ago

What drugs just turn off my brain so I can just be a blob of flesh

Alcohol.

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Angelevo 8 points a year ago

No, that would be one of the worst options. There are far better ones. Not going to advise those either though -- substance dependency is not a pleasant thing for anyone.

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Madzielle 1 point a year ago

Naw fuck that, I'd rather be a sloppy mess human than whatever the fuck "normal" standard addition humans are doing. Yeah, it's difficult, but have you met folks who don't have mental health issues? There's like a whole three of them and they're dead behind the eyes.

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CatDogL0ver -4 points a year ago

Have you read the study? It only work for people with trait of high level of forgiveness. In another word, nice people.

Are you a nice person?

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Leg 1 point a year ago

Please read the comments you're responding to. You're not making sense.

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CatDogL0ver -5 points a year ago

It didn't turn off the brain. Read the study. Only people with trait of high level of forgiveness responded. In another word, nice, forgiving people.

Are you a nice, forgiving person? It works for good people only

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FoxyFerengi 5 points a year ago

The commenter that you replied to was expressing despair at how difficult their life is because they have AuDHD. They are not saying that Tylenol can turn off their brain, they are instead asking for recommendations to escape their misery.

You could try understanding the comment chain and comments before saying something that sounds cruel like:

"Are you a nice, forgiving person? It works for good people only".

Many neurodivergent people grow up abused by their parents because of their needs, and struggle with feeling like they are not good, not good enough, and not worthy of love. Saying what you did, unprovoked, to a ND person can send someone into a self-hatred spiral that is wholly unnecessary and has nothing to do with what they actually said.

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liuther9 0 points a year ago

It might be a symptom but is it the thing that occurs only in autistic people and normal people do not experience this feeling?

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FoxyFerengi 1 point a year ago

RSD is not limited to people with autism or ADHD. It's just very common among neurodivergent folks

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liuther9 1 point a year ago

I mean I didn't get what you implying, are you telling that gov was right about acetaminophen and autism? The article just says that it can uplift the psychological pain with which I do agree as I have first hand experience

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FoxyFerengi 2 points a year ago

I was just making a joke :)

Tylenol does not cause autism. Given how often people with autism experience RSD it is funny to think that an imagined cause of autism could also be a treatment for one of its symptoms

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CatDogL0ver -2 points a year ago

Did you read the article?

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janus2 22 points a year ago

the cause of my autism is also the cure, i see

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MajorasTerribleFate 17 points a year ago

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janus2 4 points a year ago

ugh it was until i turned 27 and started getting hungover from singular beers >:(

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MajorasTerribleFate 4 points a year ago

Increased hangover even with less alcohol kicked in for me in my early 30s, but mine was likely due to interaction with prescribed medications I'm still on. Either way, my organs thank me.

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janus2 2 points a year ago

yeah I'm only half mad because i have other health issues i need to be working on, i don't need to be adding a carcinogen into the mix

plus, all the homebrew and cocktail hipsters are also getting old, so the NA beverage industry is gaining momentum

Seedlip and Pearson's spirits, Asahi Zero and Athletic beer, Lyre's cocktails, and BOLLE and French Bloom wines are some of my craft NA faves

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lightnsfw 3 points a year ago

Well there's your problem, you're not having enough beers.

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janus2 3 points a year ago

since nonalcoholic beers have gotten much better in quality and variety, i have been enjoying some lately at least

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ryannathans 3 points a year ago

Any chance ya gluten intolerant? That's how mine started

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janus2 3 points a year ago

Don't think so given the hilarious quantity of gluten I eat intentionally in the form of seitan. Fuck I really hope not. Eco-friendly cheap protein does not have an abundance of varieties 💀

I should probably do another elimination diet for a month or so to check at some point. Been a few years

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FoolishObserver 19 points a year ago

So, not only sticks and stones; now words can hurt you!

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CatDogL0ver 6 points a year ago

Yes, it is the essence. Words can hurt. That's what we have been telling people.

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elbarto777 2 points a year ago
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RizzRustbolt 18 points a year ago

You get deep enough into any emotion and it will start overlapping physical neurotransmitter pathways.

Just ask anyone thats done research into schizoid personality disorder.

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LodeMike 3 points a year ago

"The part of the computer that does one thing is connected to the part of the computer that does another thing 🤯"

Except our brains can change their wiring.

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BarneyPiccolo 8 points a year ago

It seems like a weird idea at first, but people self-medicate with all sorts of substances to ease their mental pain. Thinking of it that way, it makes sense that a pain reliever like acetaminophen might help.

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umbrella 8 points a year ago
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CatDogL0ver 3 points a year ago

It you have read the article, only for peopl with high level of forgiveness.

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zeca 7 points a year ago

Im still wondering what the helll does it mean to have "a high level of forgiveness"

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umbrella 1 point a year ago
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CatDogL0ver 6 points a year ago

You can learn to be a better person. We all can.

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umbrella 0 points a year ago
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kerrigan778 6 points a year ago

This appears to be a tiny undergrad study on something neat. I think y'all are reading too much into this. Also, there appears to be no link between acetaminophen and autism but that has absolutely nothing to do with this study.

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underscores 5 points a year ago

I have feel like that pretty often when sad, it does genuinely hurt

So it makes sense to me

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Drusas 5 points a year ago

There is also research that shows that acetaminophen is not a particularly effective pain reliever, or at least, that it is only an effective pain reliever for a subset of the population.

So I don't know how much this would prove.

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Tollana1234567 3 points a year ago

its much weaker than the non-selective cox inhibitors, naproxen, ibuprofin or even aspirin. in managing fever and pain. its only useful in mild pain that isnt chronic and not severe pain.

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lightnsfw 3 points a year ago

It works for me it also gives me a little bit of a buzz. I usually take ibuprofen though unless it's something bad in which case I take one of each.

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Beebabe 1 point a year ago

Anecdotally it doesn’t work for me, exactly. It sort of makes me feel numb and slow. So sometimes I take it specifically to get that feeling. This happens even in small doses.

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ivanafterall 1 point a year ago

Ibuprofen is the stuff of the gods.

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kalkulat 4 points a year ago

Old doctor joke: Patient: "Hey Doc, it hurts when I do this." Doc: "Quit doing that!" Same holds true of social pain. Trust yourself, stay true to yourself, avoid the pain sources, and 'find the others'.

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MajorasTerribleFate 18 points a year ago

More easily said than done, for some of us.

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Rekorse 2 points a year ago

Life is about recognizing and solving problems.

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MajorasTerribleFate 1 point a year ago

Life is also about not wasting your time on the problems that are too costly for you to resolve while you have other things to worry about.

This life is not so simple and pleasant as to give everyone the opportunity to figure out how to solve every one of their problems, least of all those whose physiology or neurochemistry make certain of those problems significantly more difficult for them than for others.

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lightnsfw 1 point a year ago

Okay but how do I avoid homelessness and starvation when the cause is going to work?

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MutantTailThing 2 points a year ago

So not that much unlike alcohol then

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Sam_Bass 2 points a year ago

I hit something a little different for my depressed attitudes and it works as good as a prescribed medication. Alpha GPC

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ryannathans 1 point a year ago

If alpha GPC (choline) works you might have methylation mutations impacting your folate metabolism. Have a look at methylfolate, b2 and methylcobalamin and maybe get your MTHFR, MTR, MTRR, COMT genes tested. The supplement trimethylglycine might do ya wonders too

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Sam_Bass 1 point a year ago

Yeah I'm not doing any of that. Already don't have a full deck to play with, so they could just call it that and fee me to the poorhouse for the priviledge. Alpha gpc's main attraction is its cheap and easy to get

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ryannathans 1 point a year ago

Alpha GPC is literally the most expensive thing on that list, those are vitamins B2, B9 and B12. You'll probably benefit from egg yolk which contains the fat soluble version of alpha GPC (choline)

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Sam_Bass 1 point a year ago

I have all that here, too and so far they've done nothing but make my pee neon yellow for a couple days. A-gpc hits me about 30 minutes after ingestion and lasts about 4 hours. At 150mg dosage it lasts me twice as long as the rda

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captainlezbian 2 points a year ago

Great now autism is going to spread from parent to children

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CatDogL0ver 2 points a year ago

Propaganda can be spread like wild fire

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stevedice 2 points a year ago

I once saw an episode of a TV show on exactly this topic. The way they simulated social pain was by telling three people they were playing a game of catch together on a computer but, in reality, each person had its own game with 2 NPCs that would eventually just leave the player out and start throwing the ball among themselves and I just think that's so mean but kinda funny.

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RBWells 1 point a year ago

Tylenol has never worked for physical pain in my experience, but can't say I ever tried it for emotional pain. Glad to hear it does something.

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Hazmatastic 1 point a year ago

You telling me I can painkiller my way away from the massive amounts of cringe I generate? Say less, lemme go buy a costco-sized barrel of excedrin

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aceshigh 0 points a year ago

So it no longer causes autism? /s

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CatDogL0ver 2 points a year ago

No and neither can 5G

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lightnsfw -1 points a year ago

No it still does but that ship has sailed at this point so might as well use it.

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ryannathans 0 points a year ago

More like proof paracetamol fucks up your brain, we already know it kills empathy

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FauxLiving 2 points a year ago

And according to America's Leading Experts™️, it causes autisim

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HeyThisIsntTheYMCA -6 points a year ago

Acetaminophen reduces fever, not pain

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aarch0x40 -19 points a year ago
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Broadfern 8 points a year ago

Taking pain meds every day because you’re in otherwise unmanageable pain is not the same as taking meds every day for the high*.

“Abusing Tylenol” isn’t a thing. There are no highs off of it, even. The problem is the cause of the pain, not the treatment.

*High != bad, and addiction isn’t a personal failure either.

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aarch0x40 -7 points a year ago
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bignate31 5 points a year ago

I use water to escape the emotional state of feeling dehydrated. and I exercise to escape the emotional state of wishing I was more physically healthy.

just throwing around the "addiction" term like this is extremely damaging to yourself and those who suffer from real addictions

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otter 7 points a year ago

Don't astroturf for the GOP.

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aarch0x40 -11 points a year ago
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otter 1 point a year ago

Wow, you're a goddamn knob, aintcha. 🫩

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aarch0x40 0 points a year ago
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CatDogL0ver 2 points a year ago

Acetaminophen doesn't cause addiction. Pls stop spreading propaganda. Acetaminophen doesn't cause euphoria and there is no withdrawal.

Spreading propaganda is addictive.

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lightnsfw 0 points a year ago

I do get buzzed when I take acetaminophen. Just on a normal dose. Can't speak to withdrawal or addiction as I don't take it much to develop that but it does have an effect.

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Tollana1234567 1 point a year ago

how are nsaid addictive? they cause significant physical damage before you can get addicted to it. you dont even get high off of nsaid.

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kerrigan778 4 points a year ago

Nobody is talking about nsaids

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