They should probably find a way to turn humans into mice. It's a shame to leave billions of dollars on the table like that.
Might be a good concept for a sci fi story actually, probably a comedic one. Scientists learn how to cure any disease and reverse aging, but only for mice. Conveniently for plot reasons, they also figure out how to turn people into mice and back. You can get any disease cured or become young again...but you have to spend three months as a mouse.
Someone that knows what they're doing: I will watch this show.
I cannot remember what but I've heard of mention of a story where because there's so many cures of disease for mice that they take over the world or something. It's such a faint mention sorry
I know of a short story on becoming a mouse, but that one's focus is something euthanasia adjacent.
Why do we not simply transplant the hair from the mice, onto the humans?
To avoid rejection of the hair follicles, simply glue live mice to the top of your head.
"Mice lie and monkeys exaggerate."
That's cause they're not on dutasteride, finasteride, or estrogen therapy. It's all the fault of DHT.
I think this is overly negative. There have been multiple significant advances in cancer treatment over the past 10 years. It just depends which type you get.
Maybe overly negative by saying they come to "nothing", but if you trace those advances back to their initial press release stage, they generally way ovehype it.
Here we have what is being heralded as maybe a universal response to any and all cancer. That would be a shockingly amazing deviation from basically all the cancer research to date. It's possible and wonderful if true, but generally the research falls short of the initial press coverage, even if it amounts to something.
while you're not wrong i do want to reiterate that mRNA vaccines are likely going to be how we treat and cure cancers so there is precedent at least for this to be massive news. if not this there will likely be a real announcement one day.
The likelihood that all cancers express a common surface marker that is never expressed by any non-cancerous cell seems pretty low. Not a cancer biologist, but there's all kind of different genetic paths to cancer - why would they all cause some specific molecule to be expressed and why would no other cell ever use it?
Your instincts are correct. The approach in the paper is more complicated than this. Here is the abstract:
Abstract The success of cancer immunotherapies is predicated on the targeting of highly expressed neoepitopes, which preferentially favours malignancies with high mutational burden. Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in poorly immunogenic tumours and that these interferon responses can be enhanced via systemic administration of lipid particles loaded with RNA coding for tumour-unspecific antigens. In mice, the immune responses of tumours sensitive to checkpoint inhibitors were transferable to resistant tumours and resulted in heightened immunity with antigenic spreading that protected the animals from tumour rechallenge. Our findings show that the resistance of tumours to immunotherapy is dictated by the absence of a damage response, which can be restored by boosting early type-I interferon responses to enable epitope spreading and self-amplifying responses in treatment-refractory tumours.
Eh a lot of them save some lives. Its just cancer is really good at killing people and there are a lot of types of cancer
It's why I start following it myself when it gets to the human trial stage and less the breakthrough stage. There, you make the assumption that they have a plan and are much more confident in the product.
I will remain eternally hopeful! Maybe someday. Maybe!
ITER is still well under way as far as fusion goes. I doubt room temp super conductors will ever be a thing though. If we can get a metalic material which superconducts above the boiling point of nitrogen then that will be world changing enough.
LOL. ITER is not and has never been meant to be a fusion power plant. That would be DEMO.
Don't hold your breath.
Fusion power will never, ever happen. Ever.
Look at CFS SPARC, not ITER
They will have an actual functioning fusion machine with Q>10 by end of this year thanks to high temperature superconductors that were not available when ITER started
Hopefully, the researchers will be fully employed by the EU. I wouldn't trust the US to not fuck up this miracle.
“How much would you pay to not die of a tumour?”
I can't want to never hear about this again
Rfk is about to wake up and fire everyone doing this research.
When we say "healthcare" we mean caring for the health of healthcare corporations.
While the formulation isn't unlike the Covid-19 vaccine, which uses lipid nanoparticles to deliver the genetic instructions to the body, it is still somewhat different. Instead of the drug encoding a virus protein, it sends a message to the immune system to rally the troops. It essentially tells the body to produce certain proteins that stimulate the immune system – including a protein within cancer cells known as PD-L1 (Programmed Death-Ligand 1), which makes tumors become more visible to immune cells.
TLDR: they are finding that it’s more effective to make cancer more visible and have the body’s immune system do its thing.
It has the potential to do away with chemotherapy, surgery and radiation treatment.
I read that as: Will never reach the market because it threatens a multibillion dollar industry.
But srsly, glioblastoma is a really nasty motherfucker with a very low patient survival rate, so if they've really managed to cure it that's a huge milestone.
In this study on mice...
Took them 7 paragraphs to get around to mentioning that.
Previous research has focused more on homing in on a target or tailoring a vaccine specific to a patient's own cancer profile.
"This study suggests a third emerging paradigm," said study co-author Duane Mitchell, MD. "What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anticancer reaction. And so this has significant potential to be broadly used across cancer patients – even possibly leading us to an off-the-shelf cancer vaccine."
So... Kinda triggering your own auto-inmune response. But I'd be wary of trouble with overtly aggressive auto-inmune responses, as we already have quite a few diseases coming from these, as well.
living with lupus
Immune checkpoint inhibitors are already a relatively common therapy for several types of cancer.
This is how I Am Legend starts.
Win/win I love people that slap Chris Rock
I want to believe.
mRNA vaccine research in America? don’t need that, cancel the funding!
Universal as in "anyone can pay big $$$ for it"
What is the catch?
It causes cancer.
Whatatweest!
A fellow Robot Chicken connoisseur, I see! You have very good taste.
Besides that, I assume it comes at the cost of...unintended consequences for the body
Too bad we got a Sociopathic Oligarchs as HSS, who thinks mRNA vaccines should be banned. Cancer is better than...well, whatever is wrong with mRNA vaccines.
Universal Cancer Vaccine? WASTE OF MONEY, CUT IT!
-The Trump Administration!
amazing. i can already hear the anti vax crowd seething lol
Conservatives will somehow find a way to level this as devil worshiping blasphemy and let their children die of brain cancer instead.
E X T E R M I N A T E^/s^
CIA hitmen:
But won’t the thimerosal in the cancer vaccine give everyone autism? Cancer is better than autism!
/s (duh)
Curing (or at least improving our treatments for) cancer would be great. There's a small part of me that absolutely does not want to see it happen within the next few years because of the current administration. It'd still be an overwhelmingly good thing to accomplish but I dread the future arguments over the time Dr. Don and Bobby got together in the lab to cure cancer through the power of Jesus, bootstraps and grit.
Sounds great, but don't get excited, it's not for you. It will be priced so that poorz can't afford it, like 5-15 mil a pop
Sweet baby Jesus, is this it? Is this finally the cure for cancer that everyone's been waiting for?
"It's not a tumor!!!!"
Biologically, this argument makes no sense, it's almost certainly written by somebody not familiar with physiology and just trying to sound poetic. That or a journalists severely misinterpreting a quote or analogy from a researcher, which also happens quite a lot.
Cancers have a gigantic variety of causes, but a purposeful signaling pathway is not one.
but a purposeful absence of preventive pathway could be one
What a load of bollocks. Natural cell mutation causes both evolution as well as unwanted side effects, of which cancerous cells are one.
Every cancer and every body is different. Why search for universal cancer vaccine insted for AI tha will analyze individual biopsy and persons blood work and came up with targetet 100 % efficient cure?
Why have we been funding researchers when the true answers have been out there on the internet, where we train our valued AI partners? See, AI could have told us we should look to AI for all the solutions! But it needs genius randos on the internet to give them these insights to train on.
He has a point though. In medicine AI actually has its uses, like spotting cancers better than humans can, decoding proteins, and solving protein folding problems.
We're of course talking about AI in the same way any scientist uses a computer, not replacing humans with a glorified text processor.
No please, no. We don't need this, please
Those in power will live longer and you're an idiot if you think that they will not be the first if not the only to receive the treatment.
Are you prepared to see Trump's fifth turn?
Cancer liberated so many souls like Hugo Chavez, Pol Pot, Suhatro, Sese Seko, Assad, Karimov, Salazar and Mugabe. This vaccine would've saved 5-15 years of their lives
@lemmy.world
A community to post scientific articles, news, and civil discussion.
dart board;; science bs
rule #1: be kind
go to feed...
@lemmy.world
A community to post scientific articles, news, and civil discussion.
dart board;; science bs
rule #1: be kind
go to feed...
I'll read the publication in the coming days and report back, but don't get your hopes up. There's a "breakthrough" in cancer research every few months and it leads to nothing. And this study was done in mice which are a bit different to humans (citation needed)
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